Studies on Complexes. XIV. Effect of Complex Formation on Drug Absorption from Alimentary Tract. (5). Enhancing the Absorption of Certain Drugs by Complex Formation
1969 年 17 巻 5 号 p. 994-998
詳細
1969 年 17 巻 5 号 p. 994-998
Attempts were made to enhance the absorption rate of drug by the complex formation. Following model complexes of rapidly absorbed drugs (A) with slowly absorbed drugs (B) were used : hydroxyethyltheophylline (A)-carbazochrome (B), caffeine (A)-carbazochrome (B), nicotinamide (A)-carbazochrome (B), and salicylic acid (A)-4-methylamino-antipyrine (B). Apparent absorption rate for a slowly absorbed drug with or without a rapidly absorbed one from rat small intestine were determined by the recirculating perfusion method at pH 6.0, and from these results and the equilibrium constant for the complex the absorption rate constants for the complexes were calculated by the equation shown in the previous report. It was found that the intestinal absorption of the drug B increased in the presence of the drug A in those complexes, and the calculated absorption rates for the complexes were higher than those of B and lower than those of A.
