Abstract
Effect of some non-ionic surfactants on the muscular absorption of Enduracidin was investigated from both the urinary and blood level studies in the rat. Addition of the non-ionic surfactants remarkably promoted the absorption of Enduracidin from the muscles of the rats and Nikkol HCO-50, hydrogenated castor oil polyoxyethylene ether, showed the most pronounced absorption-enhancing ability. It was also found that there was no correlationship between the peak blood level and the concentration of Enduracidin and that the duration of blood level was dependent on the concentration of the antibiotic. A rate-limiting process was proposed to the muscular absorption mechanism of Enduracidin from the result with EDTA.
