For the purpose of testing the biological activity, spiro [1, 2, 3, 4-tetrahydro-7-methoxy-2-methyl-5H-2-benzazepine-5, 1'-4'-hydroxycycloheptane] (IV) and its isomer (V) were synthesized by a sequence of reactions including ring enlargement of the acetoxy-1-tetralone (XXV) to a seven-membered nitrogenous ring compound (XXVI and XXVII) by the use of Schmidt reaction.
