Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Resonance Transfer of Excitation Energy between Non-steroidal Anti-inflammatory Drugs and Aromatic Amino Acids
水野 光司畑 俊一富岡 穂一
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1970 年 18 巻 1 号 p. 186-190

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The critical distance, R0, which is the rate parameter for the transfer of excitation energy by resonance between aromatic amino acids and 14 kinds of non-steroidal anti-inflammatory drugs or some of other aromatic compounds was calculated. The rank correlation between the R0 values and anti-inflammatory activity were found to be significant, and the activity of various nonsteroidal anti-inflammatory drugs were illustrated uniformly at a molecular level. Finally, a possibility of formation of electronic excited state of aromatic amino acid residues in living cell was discussed.
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© The Pharmaceutical Society of Japan
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