抄録
In order to find the effective antiviral agents, 5-alkyluracil, 3-alkyluracil, 5-alkylisocytosine, 5-alkyl-6-methylisocytosine, 3-alkyl-6-methyluracil, 5-alkyluracil-1-β-D-glucopyranoside and 5-alkyluracil-1-β-D-ribofuranoside were synthesized and screened as to their antiviral effect on both RNA and DNA containing viruses. For RNA viruses, type-1 Mahoney strain of polio virus and K-2211 strain of ECHO-28 virus were used. For DNA viruses, type-1 and type-12 strains of adeno virus and DV-96 strain of Vaccinia virus were used. Among these tested compounds, 5-butyluracil and 5-butyluracil-1-β-D-ribofuranoside were found to possess effect on both RNA and DNA viruses. Especially, the latter was more effective than the former. Moreover, the latter exerted a broader antiviral spectrum than that of 5-fluorodeoxyuridine.
