Alkylated Pyrimidine Derivatives as Antiviral Agents. II. Inhibition of Early Stages of Viral Multiplication by 5-Alkyluracil and 5-Alkyluracil Nucleoside

Abstract

The site of the inhibition of 5-alkyluracils and 5-alkyluracilnucleosides on intracellular multiplication of Mahoney strain of poliomyelitie virus and type-12 of adeno virus were investigated in Hep. No. 2 cells. Among these compounds 5-ethyuracil (EU), 5-butyluracil (BU), 5-ethyluracil-1-β-D-glucopyranoside (EUG), 5-ethyluracil-1-β-D-ribofuranoside (EUR) and 5-butyluracil-1-β-D-ribofuranoside (BUR) possessed inhibitory effect on the early phase of intracellular multiplication of Mahoney strain. Especially, BUR was more effective than the other compounds. It was suggested from the experimental results, that the site of action of BUR is the inhibition on the early phase of viral reproduction and the inhibition of viral release from host cells is probably the secondary phenomenon.