Abstract
A screening of some substances for antimetastasis effect was carried out. The test system has previously been reported. The LP-12 line of Ehrlich ascites carcinoma cells were inoculated into the tail vein of ddY mice to give pulmonary tumor foci reproducively. Drugs to be tested were injected simultaneously with the tumor inoculation. Among some known antitumor drugs, bleomycin and cyclophosphamide have shown excellent effects. Non-ionic surface active agent, Triton X-100 also has been shown to give a slight activity.
