Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Tertiary Amine Oxides. XXXVIII. Reaction of Quinoline 1-Oxide with N-Acylmethylpyridinium Salts in the Presence of Acylating Agents
MOTOYOSHI YAMAZAKIKANJI NODAMASATOMO HAMANA
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1970 Volume 18 Issue 5 Pages 901-907

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Abstract
Quinoline 1-oxide (I) was found to react readily with N-acylmethylpyridinium salts (II) in the presence of acetic anhydride to give N-(α-acyl-2-quinolylmethyl) pyridinium salts (III) in good yields, but no reaction was observed without acetic anhydride. Treatment of benzoyl-adduct of quinoline 1-oxide (Ia) with II in the presence of acetic anhydride also afforded III, but the yields of III were somewhat less compared with the former procedure.
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© The Pharmaceutical Society of Japan
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