Abstract
It has been found that cupric ion retards the rates of hydrolysis of Girard T hydrazones formed from aliphatic carbonyl compounds. The reduced rates approach to the magnitude expected for the rate-determining hydronium ion catalyzed decomposition of the intermediate amino-alcohols. Cupric ion has almost no effect of the hydrolysis of the Girard T hydrazone of acetophenone or the Girard D hydrazone of acetone. The results are interpreted in terms of an inhibition of hydrolysis through the dipolar form of amino-alcohol intermediate by cupric ion.
