Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Granulating Processes. III. The Effect of Properties of Binder Solutions on the Apparent Specific Volume and the Breaking Strength of Solid/Liquid Mixed System
JUN MITSUIRIKIZO AOYAMASHINICHIRO KAGA
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1970 Volume 18 Issue 8 Pages 1541-1547

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Abstract
The effect of properties of binder solutions on the apparent specific volume and the breaking strength of solid/binder solution mixed systems was investigated in relation to the filling properties of the mixed system. By the effect of additives, the apparent specific volume vs. amount of binder solution curves did not give a characteristic change as compared with the curve of powder/water mixed system. The work of adhesion between powder and binder solution decreased, the minimum apparent specific volume in Funicular-2 region decreased. The breaking strength of mixed systems may be composed of interparticle friction and interparticle adhesion force (tensile strength) by liquid pendular ring. The tensile strength (S) calculated from the equation S=(1-ε)σ AB/dpg was compared with the strength found. It was supposed that the breaking strengths of mixed systems are multiplicable of interparticle friction and tensile strength. The higher the viscosity of binder solution, the larger the tensile strength. The effect of viscosity was minimized efficiently by the addition of detergent. In spite of the effect of properties of binder solutions, the critical points C1 and C2 were determined on the mean capillary diameter vs. amount of binder solution curves. It was also found that the extrusion weight of granules through extrusion type granulator was inversely proportional to the breaking strength of the mixed system.
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© The Pharmaceutical Society of Japan
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