Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Spectroscopic Studies on Molecular Interactions. V. Charge-Transfer Property and Enzymatic Acetylation of Aniline Derivatives
IKUO MORIGUCHISHIZUO FUSHIMINOBUYOSHI KANENIWA
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1970 Volume 18 Issue 8 Pages 1553-1557

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Abstract
The first ionization potential, IP, of 10 aniline derivatives was estimated from the charge-transfer absorption spectra arizing in the 510-560 mμ region due to their interactions with p-chloranil. The relation of Ip to the rate of enzymatic acetylation, VAc, indicated that VAc, and possibly affinity to the enzyme, increased with an increase in charge-transfer ability of the anilines. But it was also found that VAc became greater with an increase in basicity of the anilines ; this was compatible with the theory for the usual organic acylation. Accordingly, whether or not the charge-transfer was actually concerned with the enzymatic reaction could not be determined from this study, except from the standpoint that organic ionic reactions were generally involved in the transfer of charge. The relation of IP to pKa was theoretically discussed.
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© The Pharmaceutical Society of Japan
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