Syntheses of the Urinary Metabolites of 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole (Mepirizole, DA-398)

RENZO DOHMORI; RYUICHI YOSHIMURA; SHINICHI KITAHARA; YOSHIAKI TANAKA; TAKEO NAITO

doi:10.1248/cpb.18.1908

RENZO DOHMORI, RYUICHI YOSHIMURA, SHINICHI KITAHARA, YOSHIAKI TANAKA, TAKEO NAITO

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JOURNAL FREE ACCESS

1970 Volume 18 Issue 9 Pages 1908-1914

DOI https://doi.org/10.1248/cpb.18.1908

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Abstract

All the metabolites (UAM-1, UNM-1, UNM-2, UNM-4, and URM-1), which were isolated from the urine of rats and rabbits administered 1-(4-methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole (mepirizole, DA-398) were synthesized and their structures were established by direct comparison with the synthetic samples.

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