Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Amino Acids and Peptides. I. Novel Peptide Bond Formation Catalyzed by Metal Ions. I. Formation of Glycine Peptide Esters
SHUNICHI YAMADAMITSUYOSHI WAGATSUMAYOSHIO TAKEUCHISHIRO TERASHIMA
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1971 Volume 19 Issue 11 Pages 2380-2388

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Abstract
Treatment of glycine ester with Cu (II) ion and other metal ions in a non-aqueous solution at room temperature resulted in the simultaneous formation of di-, tri-, and tetraglycine peptide esters. Each peptide ester was separated by column chromatography after carbobenzoxylation. Diketopiperazine was not formed in this reaction. Various reaction conditions were examined in detail.
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© The Pharmaceutical Society of Japan
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