Pharmacokinetic Study of Biliary Excretion. II. Comparison of Excretion Behavior in Triphenylmethane Dyes

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In the previous paper, the authors reported the kinetic studies on the factors affecting the biliary excretion with azo dyes and indigoid dye. The further investigation was tried with triphenylmethane dyes in rat. Six triphenylmethane dyes, i.e., Brilliant Blue FCF, Light Green SF, Fast Green FCF, Guinea Green B, Acid Violet 6B and Acid Violet 5B were used. (1) The excretion behaviors were similar to those of azo dyes which had the dose dependency. And the excretion ratios were generally larger than those of azo dyes except Light Green SF and Acid Violet 5B. (2) It was concluded that a sulfonate group beyond other groups had a remarkable effect on the biliary excretion ratio and pattern, and that the position of a sulfonate group as well as the number was important to determine its effect. (3) The possibility of the compartmental analysis for the biliary excretion process was suggested in the excretion pattern of Brilliant Blue FCF.