Abstract
5'-δ-Carbamoyloxy-L-x-aminovaleramido-5'-deoxyuridine, a polyoxin analog, was prepared by the reaction of 5'-amino-5'-deoxy-2', 3'-O-isopropylideneuridine and N-carbobenzoxy-L-α-aminovalero-δ-lactone, followed by carbamoylation and the removal of the protective groups. Several other ω-substituted aminoacyl derivatives were also prepared utilizing the activated ester method and the mixed anhydride method. All these compounds showed no polyoxin-activity.
