Studies on Monoterpene Glucosides and Related Natural Products. XIII. Incorporation of [10-¹⁴C]-Sweroside into Gentiopicroside and the Alkaloids in Vinca and Cincona Plants

Abstract

Feeding of [10¹⁴-C]-sweroside (I), prepared by the route shown in Chart 1, to plants established that this glucoside (I) was incorporated into gentiopicroside (III) and vindoline (VI). Substance I was also incorporated into reserpinine (VII) and quinine (V). These data confirmed the biosynthetic sequence of the gentianaceous secoiridoid glucosides and the biological conversion of sweroside (I) to Vinca and Cinchona alkaloids.