In the studies of alcoholyses of (trifluoromethyl) quinolines, 3-(trifluoromethyl) compounds (II and V) were found to be more reactive to nucleophile than other isomers (I, III, IV, and VI), which were more reactive than benzotrifluoride, in turn. Two different mechanisms are proposed for each process. Reduction of N-oxide groups with sodium alkoxides are also reported.
