Abstract
1, 2, 3, 4-Tetrahydro-2-oxo-pyrido [1, 2-a] pyrimidinium chloride (IIa) was easily obtained by the condensation of ethyl 3-chloropropionimidate hydrochloride (I) under mild conditions. On the basis of this finding, methyl derivatives of 2-aminopyridine, 2-aminopyrimidine, 2-aminopyrazine, 2-aminothiazole and 2-amino-4-methylthiazole were reacted with the imidate I and the corresponding compounds, methyl derivatives of IIa, VIa, VII, VIIIa and VIIIb, were obtained, respectively. 2-Amino-6-methylpyridine hindered the production of an expected compound. This result was also observed in the case of 2-aminoquinoline and 2-aminobenzothiazole.
