抄録
Mechanisms of pharmacological actions of phenothiazines have been known to be more or less based on the membrane actions.
As in vitro studies of the membrane action, there have been often discussed the area occupied by one molecule of each phenothiazine compound at an interface, which is also important in discussing the interaction with other drugs at the interface.
The present study was attempted to obtain the area occupied by one molecule of phenothiazines upon the adsorption from aqueous solution and the cross-sectional area evaluated from Stokes' radius of the molecule upon the permeation through cellulose membrane, discussing the results in comparison with the existing data concerning the similar values obtained from surface activity, the maximal stabilization of erythrocyte membrane and the steric structure.
