Effect of Combination of Pharmaceuticals on Gastrointestinal Absorption. III. Combination of Aminopyrine and Barbital.(1)

抄録

The combination of aminopyrine and barbital has been recomended from pharmacological point of view and claimed as one of the representative examples of drug interactions. On the other hand, it will be necessary to investigate pharmacokinetically whether such a combination exhibits a tolerable potency or not. The significantly increased plasma level of aminopyrine in rabbit after simultaneous administration of barbital was observed. The most likely reason for positive effect of barbital was investigated in detail. But the potentiation of aminopyrine-barbital interaction in gastrointestinal absorption and the accelerated effect of barbital on metabolic and excretion process of aminopyrine could not be concluded from various in vitro and in vivo experiments. As one of the reasons, an increased rate of stomach emptying induced by barbital may be presented.