Influence of Alkylamides of Glutamic Acid and Related Compounds on the Central Nervous System. II. Syntheses of Amides of Glutamic Acid and Related Compounds, and Their Effects on the Central Nervous System

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Eleven kinds of 5-alkylamides of L-and DL-glutamic acid were synthesized and assessed for anticonvulsant effects. Against lethal convulsion induced by caffeine, maximum efficacy was observed with alkylamides possessing C₇ to C₈ alkyl radicals in the position 5 of glutamic acid, and the compounds having C₅ to C₇ alkyl groups were shown to have the highest toxity. Differences in the response between L-compound and DL-compound are not significant. Synthesized ω-alkylamides of L-glutamic acid, L-aspartic acid and DL-2-aminoadipic acid did neither increase nor decrease the oxygen consumption by the rat brain cortex slices.