Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Pyrazine Derivatives. I. Synthesis of Pyrazinoylmorpholine and Related Compounds
FUMIHIKO UCHIMARUSEIZABURO OKADAAKIRA KOSASAYAMATSUNEO KONNO
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1971 年 19 巻 7 号 p. 1337-1343

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For the evaluation of biological activities, 4-pyrazinoylmorpholine (II) and many new compounds have been synthesized from the N-oxide of II. The reactions of 2-(4-morpholinocarbonyl) pyrazine 4-oxide (IV) with halogenation reagents were examined, and the main product was proved to be 6-chloro-2-(4-morpholinocarbonyl) pyrazine (VII) by correlating the product to the known 2-amino-6-chloropyrazine (XIV).
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© The Pharmaceutical Society of Japan
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