Abstract
Phosphorylation of L-ascorbic acid and its 5, 6-isopropylidene acetal with phosphoryl chloride under conditions using water as solvent and pyridine as base yielded almost quantitatively and selectively L-ascorbic acid 3-phosphate which has been a useful compound in cosmetic field. The reaction is suitable for manufacturing of the phosphate in a good yield. The effects of changes in solvent and base upon the phosphorylation reaction are also discussed by comparison of the yield and the composition of the products.
