Syntheses and Activities of Bioquinone Substances. II. Ubichromenol Phosphates and Related Compounds
1971 年 19 巻 8 号 p. 1519-1525
詳細
1971 年 19 巻 8 号 p. 1519-1525
The syntheses of ubichromenol phosphates (III, n=3, 6 and 9) and related compoundsare described. Their chromatographic and spectral data were given. Moreover, III (n=9) was hydrogenated to perhydroubichromenol phosphate (IV) which wasalso prepared through the two different ways starting from ubiquinone-(45) II (n=9).
From the results of a preliminary study of III (n=9) on the mitochondrial respirationof rat liver, it was found that the succinate dehydrogenase activity was not affected, but both the succinate oxidase and the succinate-neotetrazolium chloride oxidoreductaseactivities were inhibited, and a marked difference from the effect of ubiquinone.
