Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Antitumor Substances. XI. Reactions of Bunte Salts with Nucleophiles
SEIGORO HAYASHIMITSURU FURUKAWAYOKO FUJINOTORU NAKAOSEIICHI INOUE
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1971 Volume 19 Issue 8 Pages 1557-1561

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Abstract
In order to examine the relationship between the carcinostatic activities of Buntesalts and their chemical behaviours, several Bunte salts, in which some of them weredifunctional, were synthesized and attempted to react with several active methylenecompounds, thiols and amines. In the reactions with thiols and amines, all of the Buntesalts resulted in the formation of the corresponding disulfides or the recovery of the startingmaterials. But in the reaction with active methylene compounds, alkylmercapto orbisalkylmercapto derivatives and cyclic mercaptal were formed respectively.
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© The Pharmaceutical Society of Japan
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