Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Inhibition of Guanine Deaminase with Derivatives of Imidazole
FUMIHIKO KANZAWAAKIO HOSHIKAZUO KURETANI
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1971 Volume 19 Issue 8 Pages 1737-1738

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Abstract

Antitumor activity of 8-azaguanine was enhanced by simultaneous administration of 5-amino-4-imidazolecarboxamide (AICA). This effect was suggested to be due to the inhibition of guanine deaminase (3.5.4.3) by AICA. 1-β-D-Ribofuranosyl-and 5-formamide derivatives of AICA were not inhibitory. In continuation of a previous report, inhibitory compounds for guanine deaminase more potent than AICA were searched among derivatives of imidazole. 4-Imidazolecarboxamide was thus found as a potent inhibitor.

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© The Pharmaceutical Society of Japan
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