Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
X-Ray Analysis of the Molecular Compound of Homosulfanilamide and Sulfathiazole
THOMASF. BRENNANELI SHEFTERPHYLLIS SACKMAN
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1971 Volume 19 Issue 9 Pages 1919-1924

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Abstract
The solid state structure of a 1 : 1 homosulfanilamide : Sulfathiazole adduct was determined by single crystal X-ray diffraction. The results showed that the acidic proton of sulfathiazole is abstracted by the aminomethyl group of homosulfanilamide to form a salt. Intramolecular hydrogen bonds are also involved in the stabilization of this "molecular compound".
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© The Pharmaceutical Society of Japan
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