抄録
As a new and convenient method for the synthesis of 4-indolecarboxylic acid (1), the synthesis was started with the reduction of 3-nitrophthalimide (4) with sodium borohydride, followed by hydrolysis of the product to obtain 3-hydroxy-4-nitrophthalide (6). Treatment of 6 with 2 moles of diazomethane gave 2-methoxycarbonyl-6-nitrostyrene oxide (7) whose reductive cyclization afforded methyl 4-indolecarboxylate (2) and it was saponified to the desired 1.
