Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Isolation and Structure of Two Metabolites of a Macrolide Antibiotic, SF-837 Substance
井上 重治庄村 知子鶴岡 崇士尾本 捷二仁井田 太郎梅村 甲子郎
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1972 年 20 巻 11 号 p. 2366-2371

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M1 Substance, one of the main metabolites of SF-837, was isolated from the urine of rats, or digested solution of SF-837 with a liver homogenate, and identified as 4"-depropionyl SF-837 by direct comparison. Another major metabolite, M2 substance was isolated from the bile of rats, and its structure was proposed to be 14-hydroxyl M1 on the basis of the mass and nuclear magnetic resonance analyses.
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© The Pharmaceutical Society of Japan
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