Abstract
2, 1-Benzisoxazole derivatives were converted into 2, 1-benzisothiazoles simply by fusing with phosphorus pentasulfide in imidazole. 1-Alkyl-2, 1-benzisothiazolium salts, prepared by alkylation of 2, 1-benzisothiazoles with trialkyl orthoformates in the presence of Lewis acids, were shown to react with amines to afford 2, 1-benzisothiazoline derivatives and with glycine ethyl ester to form a 1, 4-benzodiazepin-2-one derivative by the extrusion of the sulfur atom.
