Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Isolation of Cytochrome c Abundant Mutant of Candida utilis
YOSHIHISA IWAMOTOICHIJI MIFUCHI
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1972 Volume 20 Issue 12 Pages 2613-2617

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Abstract
A mutant of Candida utilis containing about five fold amount of cytochrome c than that of a parental strain was induced by N-methyl-N'-nitro-N-nitrosoguanidine. In this mutant (I-35), repression of cytochrome c synthesis by glucose was not observed, while the parental strain was repressed cytochrome c content by glucose in medium. The amount of cytochrome c in the mutant varied from phase to phase in its growth stage. Iso-2-cytochrome c was found both in the parent and the cytochrome c abundant mutant, and was about 10% of total amount of cytochrome c in the both strains.
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© The Pharmaceutical Society of Japan
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