Studies on the New Metabolic Pathway of Anthranilic Acid in the Rat. I. Isolation and Urinary Excretion of Anthranilamide as a New Metabolite of Anthranilic Acid

Abstract

(1) A new metabolite was isolated in crystalline form from urine of rats injected with anthranilic acid. (2) This compound was identified as anthranilamide by chemical and physical analyses. (3) It has been found that the urine from rats injected with anthranilic acid contained anthranilamide in the range of 1.2-2.5%. (4) It was found that a large part of anthranilamide was transformed into other metabolites, and onlu 5% of the dose could be found as free anthranilamide. (5) The possible new metabolic pathway of anthranilic acid was discussed.