Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
The Solid Phase Synthesis of 19-Tyrosine Melittin
YOSHIRO MIURAHIROSHI SUGIYAMAYUJI MAKISHUICHI SETO
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1972 Volume 20 Issue 2 Pages 215-218

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Abstract
19-Tyrosine melittin, H-Gly-Jle-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Tyr-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2, was synthesized by the solid phase method using with the automatic instrument.It was obtained in 21% yield based on the amount of gultamine initially esterified to the resin.The hemolytic activity of that compound was examined.
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© The Pharmaceutical Society of Japan
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