Abstract
7-Substituted 1, 3-dimethyl-7H-2, 4, 6-(5H, 6H) pyrrolo [2, 3-d] pyrimidinetriones (IIIa, b, c) were prepared from 6-amino-1, 3-dimethyluracil (I) and ethyl α-bromoacetate. Reactionof I and α-bromo-ketones afforded 6, 7-disubstituted 1, 3-dimethyl-7H-2, 4-pyrrolo-[2, 3-d] pyrimidinediones (IV, V, VI). On the other hand, reaction of 6-mercapto-1, 3-dimethyluracil (VIII) and cc-bromocarbonyl compound afforded thieno [2, 3-d] pyrimidines (X, XI).
