Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Reaction of Biguanides and Related Compounds. II. Reaction of Biguanides with Benzil
MITSURU FURUKAWAYOKO FUJINOYOKO KOJIMASEIGORO HAYASHI
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1972 年 20 巻 3 号 p. 521-525

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Heating of 1-substituted biguanide with benzil in ethanol was found to give 2-substituted guanidilidene-5, 5-diphenylhydantoin, which was easily converted into 1, 1-diphenyl-1-substituted biguanidoacetic acid by hydrolysis with hydrochloric acid. The structureand the formation mechanism of 2-substituted guanidilidene-5, 5-diphenylhydantoin was also discussed.

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© The Pharmaceutical Society of Japan
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