Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on the Structure of Itaconitin. VIII. Synthesis of Methylanhydroitaconitin
SHOICHI NAKAJIMAYOSHIKO KOIKESHIGEKO KATO
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1972 Volume 20 Issue 4 Pages 751-754

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Abstract
Methylanhydroitaconitin was synthesized from 4-(2-methoxy-4-methylphenyl)-3-butenoic acid, which was derived from 2-methoxy-4-methylbenzaldehyde by heating with sodium succinate and acetic anhydride. The difference, of temperature in the latter reaction caused the formation of 1, 4-bis (2-methoxy-4-methylphenyl)-1, 3-butadiene. Methylstyrylmaleic anhydride was also prepared.
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© The Pharmaceutical Society of Japan
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