Studies on the Organic Fluorine Compounds. IX. Reactions of (Trifluoromethyl) quinolines with Metal Hydrides

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Reduction of (trifluoromethyl) quinolines by nucleophilic attack of hydride was studied. Sodium borohydride reduced only 3-(trifluoromethyl) quinoline to methyl derivative, while lithium aluminum hydride reduced other isomers to methylquinolines and 3-(trifluoromethyl) quinoline to 3-(difluoromethyl)-1, 2-dihydroquinoline. The mechanisms were proposed.