Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on the Stability of Amides. II. Intramolecular Hydrogen Bond in 4-Hydroxyvaleramide
山名 月中辻 彰水上 勇三
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1972 年 20 巻 5 号 p. 922-926

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Study of the intramolecular hydrogen bonding in 4-hydroxyvaleramide was undertaken to ascertain its correlation with the intramolecular catalyzed hydrolysis of amides. The presence of a strong intramolecular hydrogen bond in the amide was confirmed by infrared spectral analysis in chloroform solution. These results were supported by the stabilization energy obtained from the molecular orbital calculation of the configuration models of 4-hydroxyvaleramide.
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© The Pharmaceutical Society of Japan
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