Abstract
The metabolism of 35S-labeled saccharin, o-, p-toluenesulfonamide (TSA), o-and p-sulfamoylbenzoic acid (SBA) was investigated in rats and guinea pigs. Saccharin was rapidly excreted unchanged ; almost in urine in guinea pigs, while about 70% in urine and the remainder in feces in rats. It was suggested that such a difference of excretion patterns in the both animals might be due to the different absorption rate in stomach presumed from the observation of distinct pH values of their gastric juice. The urinary excretion of o-and p-TSA in rats was approximately 80% of those compounds administered, halves of which were oxidized to o-and p-SBA respectively by the oxidation of the methyl group. More than 90% of o-and p-SBA were excreted unchanged in rats, but the excretion ratios shared in urine and feces were considerably variable in individual animals.
