Abstract
The site specificity in the absorption of sodium taurocholate (STC), one of the most common bile salts, and its consequence on drug absorption was investigated in the rat using the in situ perfusion technique. The absorption of STC by the jejunum was negligible both below and above the critical micellar concentration and it was absorbed solely by the ileum. Marked but variable change in absorbability of drugs was observed depending upon the physicochemical nature and the absorptive characteristics of drugs. The extent of the bile salt enhancement of the absorption of sulfaguanidine was more predominant in the ileum than in the jejunum, while the inhibitory effect of STC on the absorption of imipramine was less remarkable in the ileum. Possible mechanisms of these site specificity was discussed.
