Catalytic Hydrogenation of Tetrahydro-4H-1, 3-oxazin-4-ones and 4-Oxazolidinones

抄録

For the present investigation on catalytic hydrogenation the compounds in which both amide nitrogen and ether oxygen are bound to the same carbon were provided as several cyclic compounds such as tetrahydro-4H-1, 3-oxazin-4-ones and 4-oxazolidinones, the former being newly prepared in the present work. Our objective was to know the condition of possible hydrogenolysis, which may proceed at either one of the two carbon bonds. The hydrogenolyses proceeded in acetic acid solvent over palladium-on-charcoal catalyst under high hydrogen pressure and, from the results of product analyses, were shown to be selectively effected at the carbon-oxygen bond of the compounds.