Abstract
The metabolism of prolintane (1-phenyl-2-pyrrolidinopentane hydrochloride) in rabbits has been performed in this study. Rabbits receiving the drug in oral dose of 270 mg/kg or 170 mg/kg excreted seven metabolites together with a trace of unchanged drug in the 24 hr urine. They were shown to be lactam, phenol, alcohol, lactam phenol, diastereoisomeric two lactam alcohols and amino acid, by infrared, nuclear magnetic resonance and mass spectra. Some of these were unequivocally identified by comparison with authentic samples. From these results, it is concluded that the major metabolic oxidation occured at pyrrolidine and aromatic ring to form lactam and phenolic metabolites, respectively. Penultimate oxidation of alkyl chain was seemed to be the minor reaction.
