Studies on the Metabolites in Urine and Feces of Rat after Oral Administration of Radioactive Pantethine

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This is the first report describing identifications of PaSSO₃H in nature and P-PaSSO₃H in mammals. Rats fed with solid feed containing PaA excreted PaA and P-PaA in urine, and PaA, P-PaA and PaSS in feces. When ¹⁴C-PaSS was orally administered to the rats, 15-35% of the radioactivity was excreted in a week. The amount of radioactivity excreted into urine was about double to that excreted into feces. The metabolites identified are : PaA, PaSS, P-PaA and/or PaSSO₃H and P-PaSSO₃H from urine, and PaA, PaSS, PaSSO₃H, P-PaA from feces. The possible formation mechanisms of PaSSO₃H and P-PaSSO₃H in rat were discussed.