Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Some Non-hormonal Properties of 17β-Hydroxy-17α-methyl-5α-androstano [2, 3-c] furazan (Furazabol)
TAKESHI ONODERA, TAKESHI HASHIZUME, AKIRA KASAHARA
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1973 Volume 21 Issue 1 Pages 21-24

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Abstract
Furazabol showed non-specific inhibitory activities to the responses of guinea pig ileum to various spasmogens, and the activities were considerably higher than those of papaverine. It inhibited also the response of guinea pig υas deferens to adrenaline, depressed spontaneous movements of guinea pig atria and rat uterus and showed a slight and temporal fall in blood pressure which was not affected by the pretreatment of atropine. These data suggest that furazabol has a papaverine-like property. Furazabol showed serum cholesterol-lowering action in normal rats and cholesterol-fed chicks. In addition, it exerted curative action on gastric stress ulcer in rats.
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© The Pharmaceutical Society of Japan
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