Abstract
As one of the 10-aza-steroid system, 17-acetoxy-10-aza-androstan-7-one (1) was synthesized. Condensation of hexahydroindanone (16) and ethyl piperidinoacetate (3) gave a mixture of βA-amino-enones with angular (17) and linear (18) structures. The separated 17 was reduced and then oxidized to 1. Reaction between 3 and testosterone (7) mainly gave amino-dienone (8) of linear structure. Such a tendency was also seen in the case of tetrahydroindanone (14) and the amino-dienone (19) of linear structure was obtained solely.
