Stereochemical Studies. XXVII. Total Synthesis of (+)-Mesembrine with Asymmetric Synthesis using Proline Derivative

Abstract

Asymmetric synthesis of 4, 4-disubstituted 2-cyclohexenone with enamine alkylation was successfully applied to the total synthesis of (+)-mesembrine. The assignment of the absolute configuration for synthetic (+)-mesembrine was consistent with the configuration of natural (-)-mesembrine determined by X-ray crystallography.