Nucleosides. LXXX. Synthetic Studies of Nucleoside Antibiotics. 10. Synthesis of 1-[2, 3, 4-Trideoxy-4-(sarcosyl-D-seryl) amino-β-D-erythrohex-2-enopyranosyluronic acid] cytosine, the Nucleoside of Blasticidin S Bearing the Dipeptide of Gougerotin

Abstract

A"hybrid"which contains the nucleoside moiety of blasticidin S and the dipeptide group of Gougerotin was synthesized by step-wise linkage of sarcosine and D-serine to cytosinine using the dicyclohexylcarbodeimide (DCC) procedure.