Heterocycles. V. Syntheses and Structures of 7-Chloro-2-hydrazino-5-phenyl-3H-1, 4-benzodiazepines and Some Isomeric 1, 4, 5-Benzotriazocines

抄録

2-Hydrazino-1, 4-benzodiazepine derivatives, III and X, were synthesized from the corresponding 2-amino derivatives Ia and Ib, respectively. It was found, on the other hand, that the reaction of a 2-chloromethylquinazoline 3-oxide (XIII) with hydrazine did not form X but gave a 2-hydroxyamino-1, 4, 5-benzotriazocine (XIV), which, after hydrogenation over Raney nickel, afforded its deoxygenated compound (XV). The structures of these diazepines and the isomeric triazocines were determined on the basis of chemical and physico-chemical behavior. Novel tricyclic compounds, s-triazolo [4, 3-a] [1, 4] benzodiazepines IX and XII were also prepared.