Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
The Routine Fitting of Pharmacokinetic Data to Multiexponential Equation
小泉 保上田 道廣掛見 正郎
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ジャーナル フリー

1973 年 21 巻 11 号 p. 2549-2556

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抄録
An iterative least square method for finding the best fit multiexponential equation to observed data is presented. A computer program is written in ALGOL, which permits the routine fitting of pharmacokinetic data. Given a set of data, number of exponential terms and initial estimates for exponential parameters, the computer program automatically proceeds to obtain a least square fit of the data by an iterative adjustment of the values of the parameters. Numerical tests on published data confirm its applicability.
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© The Pharmaceutical Society of Japan
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