Abstract
Solid phase synthesis of H-Arg-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH was accomplished by two different approaches, stepwise chain elongation and fragment condensation. Two fragments, Boc-Ala-Glu (OBzl)-Gly-OH (II) and Boc-Phe-Ser-Trp-Gly-OH (IV), were used for fragment condensation. Overall yields of the decapeptide were 10% in stepwise chain elongation and 34% in fragment condensation respectively. A failure pentapeptide, H-Phe-Ser-Trp-Gly-Arg-OH, was isolated in the two procedures.
